venofer dosing calculator

Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. This calculator will help pinpoint potential causes of anemia based on Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. If you log out, you will be required to enter your username and password the next time you visit. Official Journal of the International Society of Nephrology. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Am J Hosp Pharm. Below the form there are further instructions on how to use the calculator. DICP. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Avoid or Use Alternate Drug. Recommended dosing and infusion rates for PI. Copyright 1993-2021 iron sucrose increases levels of calcium chloride by enhancing GI absorption. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. Avoid or Use Alternate Drug. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. FERAHEME met the predefined criteria for non-inferiority to Venofer . Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Slowing the infusion rate may alleviate symptoms. Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. Reactions have occurred following the first dose or subsequent doses of Venofer. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. 1990 Feb;24(2):162-6. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. Venofer is given as an infusion into a vein. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Minor/Significance Unknown. There are physiological variation in iron reserves such as the decrease during menstruation period. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). The elemental iron product used is Iron sucrose 20 mg/mL. Avoid or Use Alternate Drug. Minor/Significance Unknown. Burns DL, Mascioli EA, Bistrian BR. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Anemias. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Step 2: Calculation and administration of the maximum individual iron dose(s): . Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. To view formulary information first create a list of plans. This topic . Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] Minor/Significance Unknown. Use Caution/Monitor. The dosage of iron sucrose is expressed in mg of elemental iron. 1000 mg. 20 MINUTES. Applies only to oral form of both agents. Minor/Significance Unknown. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. All Rights Reserved. 2. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Venofer must only be administered intravenously either by slow injection or by infusion. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. 1 ,*. Intravenous iron sucrose: establishing a safe dose. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Use Caution/Monitor. Use Caution/Monitor. Minor (1)iron sucrose, benazepril. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Use Caution/Monitor. Applies only to oral form of both agents. Minor/Significance Unknown. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. May increase risk of hypotension. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Applies only to oral form of both agents. Adults and Children over 15 kg (33 lbs): Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target Hb in g/dl. 5. 1996 Aug;11(4):139-46. Jacobs P, Dommisse J. Separate dosing of tetracyclines from these products. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Minor/Significance Unknown. Applies only to oral form of both agents. Applies only to oral form of both agents. Initial infusion rate. Iron deficiency anemia is the type of anemia caused by iron depletion. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Minor/Significance Unknown. Discard unused portion. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Use Caution/Monitor. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Applies only to oral form of both agents. Oral and parenteral products - see background option for oral products. Venofer has not been studied in patients younger than 2 years old. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Anemia caused by the depletion of iron is called iron deficiency anemia. Applies only to oral form of both agents. Administer on 5 different occasions over a 14 day period. Share cases and questions with Physicians on Medscape consult. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Applies only to oral form of both agents. Either decreases levels of the other by inhibition of GI absorption. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. . Use Caution/Monitor. Your doctor will do laboratory tests to monitor your response. Modify Therapy/Monitor Closely. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Schweiz Med Wochenschr. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Applies only to oral form of both agents. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. The iron formulation choice remains for the clinician to make. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Comparable efficacy to that of IV iron sucrose. No additional iron to replenish stores. Iron Product. iron sucrose, captopril. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Separate dosing of tetracyclines from these products. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Do not administer Venofer to patients with iron overload. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Applies only to oral form of both agents. Interaction only with oral iron administration. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Use Caution/Monitor. Applies only to oral form of both agents. Minor/Significance Unknown. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. 1) Ganzoni AM. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Applies only to oral form of both agents. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. Use Caution/Monitor. Formula for calculating the required dose of iron sucrose 1. Avoid or Use Alternate Drug. Minor/Significance Unknown. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Administer Venofer early during the dialysis session (generally within the first hour). Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Oral and parenteral products - see background option for oral products. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Kidney Int. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. All Rights Reserved. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) This website is intended for use by US healthcare professionals only. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Avoid or Use Alternate Drug. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Compare formulary status to other drugs in the same class. This website also contains material copyrighted by 3rd parties. This drug is available at a higher level co-pay. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Use Caution/Monitor. Either decreases levels of the other by inhibition of GI absorption. Venofer must only be administered intravenously either by slow injection or by infusion. Separate dosing of tetracyclines from these products. Anemia; 2015: 763576. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Use Caution/Monitor. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Applies only to oral form of both agents. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Pain, swelling, or redness at the injection site may occur. ]Venofer treatment may be repeated if iron deficiency reoccurs. David McAuley, Pharm.D. Creating an account is free and takes less than 1 minute. Each mL contains 20 mg of elemental . The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. Minor (1)iron sucrose, captopril. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr.

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